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Toda et al., "Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues," Diabetes, vol

Due to (temporarily) reduced sodium reuptake while continuously promoting glucosuria, these drugs induce a reduction in GFR likely via activation of tubuloglomerular feedback (TGF) that may represent reduced intraglomerular pressure [5]

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The injury mechanisms can have the following effects: hepatitis, cholestasis, vascular lesions, or overlapping changes