In my practice, Im pretty lenient about giving GLP-1 medications
This work therefore adds an additional layer of regulation for GLP-1/Notch activity, namely that the interaction between a Delta-like membrane-bound ligand and the Notch receptor at the surface of stem cells within an adjacent tissue is favoured by increasing levels of COL IV, and thus most likely the stiffness, of the surrounding basement membrane 34
Because of the increased requirements applicable to these types of studies, it is critical that companies conducting these studies carefully structure their drug development programs to ensure that all studies are appropriately capturing the level of detail and thoroughness which FDA will require when reviewing an NDA
doi: 10.1056/NEJMoa1411892, 115 PlamboeckA.VeedfaldS.DeaconC
Both peptides show promise, but using them wisely and safely is key to seeing results.
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