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The heterogeneity in this study was substantial, and we speculate that most of the heterogeneity may have come from clinical sources

Less commonly, polymorphisms in the MC1R gene (common in individuals with red hair and Fitzpatrick type I skin) reduce receptor responsiveness to exogenous agonists, requiring higher doses or longer loading phases to achieve visible results

Frequent removal from refrigeration for dosing accelerates degradation

Diabetic retinopathy Diabetic retinopathy is a complication of type 1 and type 2 diabetes that may lead to vision loss

Therefore, its hard to know exactly what the benefits will be and when you first see a patient. But he adds that research shows a connection between how you initially respond to GLP-1s and how it may benefit you long-term

Hepatology 192 TurchiJ