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4.1 Interaction between fungal virulence factors and host mitochondria Fungal virulence factors directly target host mitochondria, profoundly disrupting bioenergetic and immune functions

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This creates a boundary between the CNS and peripheral circulation for regulating blood-CNS exchange ( The BBB is critical to the maintenance of brain homeostasis as it regulates the entry of macromolecules, ions, and neurotransmitters from the blood to the brain (Wilhelm and Krizbai, 2014