It was then discovered that GLP-1 is rapidly degraded by the enzyme DPP4, giving rise to the development of GLP-1 receptor agonists (RAs) and DPP4 inhibitors for the treatment of type 2 diabetes (T2D), and GLP-1 RAs for the treatment of obesity
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It is the target of several US FDA approved anti-diabetic medications, such as: These drugs block the degradation of incretins (GLP-1 and GIP) by DPP-4, and potentiate insulin secretion following food intake
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Semaglutide injections, in particular, are commonly prescribed for these purposes