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Following other expanded indications (opens a new window) for GLP-1s, Wegovy has now received FDA approval for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced fibrosis

In vitro models suggest this supports lysyl oxidase, which contributes to collagen and elastin crosslinking, and superoxide dismutase, an important antioxidant enzyme

These may include nausea, reduced appetite, vomiting, diarrhea, constipation, abdominal discomfort, or reflux

doi: 10.1016/j.cmet.2013.04.008 21 ChegeniMHayesAMRGonzalezTDManderfeldMMLimJMenonRSet al