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Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]
It has been the subject of over 130 peer-reviewed publications since the 1990s
The 0.9% concentration represents the standard pharmaceutical formulation established in the United States Pharmacopeia (USP)
MIC injection side effects are generally mild and may include injection site reactions such as pain, redness, or swelling, as well as gastrointestinal discomfort, nausea, and in rare cases allergic reactions
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Several compounds with less theoretical concern about angiogenesis may serve as alternatives
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