Are under 18 years old
2.2.5 Metabolic reprogramming Metabolic reprogramming refers to the process in which cells, under specific physiological and pathological conditions, systematically adjust and transform their metabolic patterns to adapt to changes in the external environment and to meet their own needs for growth and differentiation, by engaging various bioenergetic routes, such as glucose utilization, lipid metabolism, and amino acid metabolism (Xia et al., 2021
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1) as well as higher mitochondrial mass and tighter cristae (Fig
Thats why its pushed at the end of treatment
In this complex scenario, the concomitant presence of obesity further increases insulin resistance and exacerbates the clinical presentation of PCOS