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4 *Data comes from a 2018-2023 US Data Base of payor claims as a retrospective, observational analysis

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For example, some people taking GLP-1 medications have reported digestive tract side effects such as nausea, vomiting, and diarrhea

References Giles A, Foushee J, Lantz E, Gumina G

Key properties: Stimulates GH release from the pituitary (not the hypothalamus) Does not significantly raise cortisol or prolactin Short half-life (~2 hours) produces a sharp, pulsatile GH release Does not block somatostatin (the hormone that inhibits GH release) Selective for GH minimal effect on other hormones The selectivity is what makes ipamorelin the preferred GHRP for most protocols

These drugs have shown efficacy beyond glycaemic regulation, including significant weight loss, cardiovascular protection, and possible advantages for renal function