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Below is a comparison using available clinical evidence

Although less common in this form than cyanocobalamine and methylcobalamine, hydroxocobalamine is also available as pills for oral or sublingual administration

The clinical trials that showed disappointing results used oral administration

The frequency of B12 IM injections can vary based on individual needs and the severity of B12 deficiency

Standard protocols use 50100 mg/kg via oral gavage or supplemented drinking water, per institutional guidelines

Importantly, these changes were observed without significant reductions in food consumption, pointing to enhanced energy metabolism rather than appetite suppression as the primary mechanism