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People who were overweight or obese lost significant weight while taking retatrutide, which enabled them to be more active and reduced knee pain by an average of 4.5 points or about 76% based on pain scores from whats known as the Western Ontario and McMaster Universities Osteoarthritis Index

GLP-1 receptor agonists exert their effect by binding to GLP-1 receptors in multiple tissues and organs

Additionally, delayed gastric emptying could worsen symptoms in patients with stricturing disease or increase obstruction risk, making tolerability a significant concern

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Cumulative benefit shows up as fewer missed training days, not as added muscle mass directly

Post-Gastric Bypass Patients For patients who have undergone Roux-en-Y gastric bypass (RYGB), vitamin B12 deficiency is a common issue due to malabsorption