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1 2 The Australasian Journal of Dermatology
We observed, that patients who developed PHLF displayed 2.3-fold higher GLP-1 plasma concentrations preoperatively, compared to patients without PHLF ( p = 0.030)
Based on Phase 2 safety data (Jastreboff et al., NEJM 2023), common early adverse effects reported include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea or constipation Reduced appetite Mild fatigue or dizziness These effects are consistent with the GLP-1 receptor agonist class and typically reflect the gut's adaptation to altered gastric emptying and hormonal signalling
Ensure youre getting enough lean protein, complex carbohydrates, and healthy fats
Our study describes a novel action of GLP-1 signalling in -cells, which stimulates metabolic/bioenergetic reprograming resulting in a high glycolytic/high ATP generating phenotype, as detailed in (Fig
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