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Conclusion Our study reveals that the activation of NLRP3 inflammasome caused by mitophagy dysfunction plays an important role in cardiac hypertrophy induced by pressure overload, and semaglutide ameliorates the cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome

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DOI: 10.1007/s12325-025-03194-8 Hoog MM, Kan H, Deger KA, et al