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These findings demonstrate that GGT activity is sufficient to support GSH catabolism and survival of surrounding cells in cystine-depleted conditions

While these findings have not been linked to serious adverse outcomes so far, they highlight the need for long-term safety studies, which are currently underway in Phase 3 trials

Knura M, Garczorz W, Borek A, Drzymaa F, Rachwa K, George K, et al

The and subunits are cleavage products of a 1367-amino acid IGF-IR precursor (12)