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BDG induced increased phagocytic capacity of human monocytes in a GSH-dependent manner ( Figure 7C )
Effects of caffeine on the pVTA biochemical profiles in alcohol-treated rats In order to detect additional mechanisms of action of caffeine independent from salsolinol formation and bioavailability, untargeted metabolomics analysis of rats pVTA was used to assess potential changes in the biochemical profiles in response to alcohol or water treatment, with or without caffeine pre-treatment
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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling
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