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Protein background The insulin-like growth factors (IGFs) are a family of proteins with a similar structure to insulin

Lipid peroxidation in cell membranes stimulates phospholipase enzymes (including phospholipase A2), which triggers the arachidonic acid cascade catalyzed by cyclooxygenases and lipoxygenases (38)

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Clinically, HT presents with local symptoms due to neck compression and systemic symptoms due to hypothyroidism (Caturegli et al