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Smoking worsens RA and makes biologic therapies less effective

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Dosing, Safety, and Regulatory Status None of these five peptides carry FDA approval for human use, and research dosing ranges vary widely by compound, from BPC-157's 10 mcg/kg to 10 ng/kg range tested in animal and early clinical work, to TB-500 protocols often run in loading-then-maintenance cycles

The pattern is clear: endogenous peptides are built for fast, local signaling and rapid clearance