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doi: 10.1161/CIRCULATIONAHA.125.074545 Summary Keywords cardiovascular outcomes, SGLT2 inhibitors, GLP-1 agonists, combination therapy, heart failure, renal outcomes Citation Aristizbal-Colorado D, Corredor-Rengifo D, Sierra-Castillo S, Lpez-Corredor C, Vernaza-Trujillo D-A, Weir-Restrepo D, Izquierdo-Condoy JS, Ortiz-Prado E, Rico-Fontalvo J, Gmez-Mesa J-E, Abreu-Lomba A and Rivera-Martnez W-A (2025) A decade of progress in type 2 diabetes and cardiovascular disease: advances in SGLT2 inhibitors and GLP-1 receptor agonists a comprehensive review
-blockers have been shown to reduce mortality through various mechanisms, including the blockade of adrenergic receptors and reductions in heart rate, which can profoundly affect cellular metabolism and energy utilization (Cullington et al., 2012)
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Novo Nordisks Canadian patent for semaglutide expired in 2020 due to a missed maintenance fee
Yes, but only in limited cases
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