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Although it has not yet been FDA-approved specifically for obesity, tirzepatide demonstrated significant weight reduction when analyzed as the secondary outcome in SURPASS trials and as the primary outcome in the SURMOUNT I trial
Current evidence supports safe use for at least four years based on the SELECT trial
BonnardCDurandAPeyrolSChanseaumeEChauvinMAMorioBet al
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Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease Nature Medicine Phase 2a trial demonstrated retatrutide 12 mg achieved 82.4% mean reduction in liver fat at 24 weeks, with 86% of participants normalizing liver fat levels below 5%
Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide
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