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However, given that large peptides like GLP-1 interact with both the extracellular and transmembrane domains of the GLP-1R ( 32 ), and that our small molecules were unlikely to recapitulate this complex binding mode, it was unclear whether the competition binding experiments with radiolabeled GLP-1 were providing an accurate measure of affinity ( 25 )

Novo JP, Martins B, Raposo RS, Pereira FC, Ori RB, Malva JO, Fontes-Ribeiro C (2021b) Cellular and molecular mechanisms mediating methylmercury neurotoxicity and neuroinflammation

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If these contraindications apply to you, I still encourage scheduling a consultation so that our team and I may help you find a good alternative

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