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Yes, tirzepatide and tamoxifen operate through completely different biological pathwaystirzepatide works on appetite and insulin sensitivity, while tamoxifen blocks estrogen signaling on cancer cells
If you are making significant changes to your metabolism through medication and weight loss, it is only logical that your "thermostat" might need checking and adjusting
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Starting too aggressive can cause: Different GI effects than you're used to Unexpected energy fluctuations Appetite changes that don't match your tirzepatide experience Give yourself one week at your starting dose to see how the glucagon piece hits you specifically
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