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While some high-quality studies, such as the STEP 1 and SUSTAIN 8 studies, show a significant proportion of weight loss as lean mass, data from across studies suggests an overall improvement in body composition for many patients and even potential protective effects against muscle wasting
Camacho, P
Semin Thromb Hemost
Abstract Glucagon-like peptide-1 (GLP-1) is a 30-amino acid hormone secreted by L cells in the distal ileum, colon, and pancreatic cells, which participates in blood sugar regulation by promoting insulin release, reducing glucagon levels, delaying gastric emptying, increasing satiety, and reducing appetite
Longer-Term Timeline: Effects Beyond About 4 Weeks, And What We Still Do Not Know Most people see a decline in common side effects by four weeks
When liver function is compromisedby poor diet, alcohol, medications, or simply agefat accumulates in liver cells (hepatic steatosis)
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