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A review of 39 clinical studies found that IGF-1 and growth hormone administration showed increased bone resorption and bone formation

But these levels naturally decline with age and drop even further in response to chronic stress, inadequate sleep, poor dietary protein intake, heavy alcohol use, and prolonged exposure to environmental pollutants

Endogenous (naturally produced) HGH surges during sleep and intense physical activity, but levels begin to decline significantly with age

Researchers controlled for maternal infections, autoimmune diseases, and other potential confounders

This leads to higher absorption and zero emergency bathroom trips during a run