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Precursors of glutamate (Gln) Gln acts as a precursor of glutamate (Glu), equivalent to being an indirect glutathione precursor
Structural modifications allow them to stay in circulation for hours or even days: IGF-1 LR3 : 2030 hour half-life CJC-1295 with DAC : 58 day half-life PEG-MGF : detectable for up to 12 weeks Pharmacokinetic enhancements such as PEGylation or fatty acid acylation extend the peptides residence time, reduce renal clearance, and improve therapeutic utility. Veronese & Mero, BioDrugs What Determines How Long Peptides Stay in Your System
"The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus"
Lin, N., Erdos, T., Louie, C., Desai, R., Lin, N., Ayzenberg, G., & Venketaraman, V
Annual Meeting Report
doi:10.1111/j.1460-9568.2011.07957.x
