The adventitia of atherosclerotic arteries is innervated by sensory and sympathetic fibres and contains clusters of immune cells, forming the neuroimmune CV interfaces ( 2.3 Mechanisms of heart-brain interactions 2.3.1 Neuroinflammation and systemic immune response Both ischemic and hemorrhagic stroke induce neuronal cells necrosis, leading to increased blood-brain barrier (BBB) permeability and disruption of the structure and function of the neurovascular unit (NVU) (Figure 2)
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