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New VA data from over 600,000 individuals with type 2 diabetes shows GLP-1 receptor agonist use was associated with a lower risk of developing a substance use disorder
PMID 10428973
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The STEP trial series, which enrolled over 4,000 participants, showed depression rates similar to placebo groups
Safety Monitoring Framework for Dual Therapy Safe concurrent use of GLP-1 and berberine depends on regular clinical assessment including fasting glucose, HbA1c, liver function tests, and kidney markers
Standard-dose protocols are usually the better fit when the patients primary goal is significant weight reduction and they are comfortable with a more traditional titration plan
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