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Additionally, Tianlongkechuanling (TL) mitigates fibrosis by reducing the expression of multiple arginine cycle enzymes, including arginase-1, CPS1, OTC, ASS1, OAT, ASL, and iNOS, helping to restore the balance between arginase and NO synthase pathways [140]
doi: 10.1172/jci116842
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Cysteinylglycine or -glutamylcysteine have been proposed as possible alternatives.In a trial of adolescents with poorly controlled type 1 diabetes, a dose of 30-45mg/kg/day NAC failed to correct several markers of glutathione status, suggesting either a higher dose or alternative therapies may be indicated in this population.A recent study of patients with poorly controlled type 2 diabetes found that dietary supplementation of the amino acids cysteine and glycine, markers of glutathione synthesis and plasma oxidative stress were both improved