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Availability of data and materials The datasets generated and analysed during the current study are available in the NCBI repository, the accession number is SRP314907

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For example, variant X(GD_L)c.3 (later renamed X(GD_L)f) had a catalytic efficiency of 0.004 M 1 s 1 , whereas the parent X(GD_L)c that lacked reversion and engineering showed no detectable activity on the FRET substrate (Fig

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REDEFINE-1 showed that adding amylin to a GLP-1 backbone improves results

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