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76 For instance, AARS1 functions as an intracellular lactate sensor, directly binding lactate to form lactate-AMP, and mediates lactylation of K120/139 on p53 within its DNA-binding domain (DBD), which prevents the binding of p53 to DNA containing p53 response elements (p53RE-DNA) and subsequent p53 liquidliquid phase separation (LLPS)
After induction of hypertone, a strong positivity to Ub is detected (lane 3), which is significantly reduced in the retina concomitantly treated with carnitine (lane 2)
Its only natural to consider any safety issues or risks associated with use, as well
The impact of mild sunlight exposure alone was found to be negligible
such as active BAAs
