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634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors

Such approaches will be necessary to determine when altered eating experience reflects transient adaptive effects, clinically meaningful nutritional consequences, persistent remodelling of food reward, or different combinations of these processes across individuals receiving GLP-1RA therapy

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