Toxins from gut microbiota can induce ER stress, triggering the unfolded protein response
These receptors can be found throughout the brain, thyroid, adrenal glands, fat tissue, pancreas, and muscular heart tissue
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These results indicate that there are probably extensive RNA processing defects in ALS patients with FUS/TLS mutations, both arising from direct effects of mutant FUS/TLS and indirect effects from altered activity of other RBPs whose levels or properties are changed by mutant FUS/TLS
Target proteins with K63-linked ubiquitination are localized to the plasma membrane, which is closely associated with the function of FSP1 in suppressing ferroptosis