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GLP-1 works by mimicking the action of a natural hormone called glucagon-like peptide-1
Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation
Historically, obesity has been an area of a lot of failed drug development
Neelakantan H, et al
Berberine, a traditional Chinese medicine, reduces inflammation in adipose tissue, polarizes M2 macrophages, and increases energy expenditure in mice fed a high-fat diet
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