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Titration schedules in phase 3 trials of long acting insulin analogues incorporated individualization to allow the clinician to increase the dose to achieve optimal benefit without causing hypoglycaemia ( The oral obesity medications The oral GLP-1 based agents approved for obesity treatment deliver substantial weight loss

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The rest of the outcome variables, nutritional status, body composition, biochemical data, and cognitive function, did not show any significant differences between the L-carnitine and placebo groups in the percent of mean changes in the intervention period