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Retatrutide is a 26-amino acid triple agonist that adds glucagon receptor activation to those two pathways
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Kidney Int 68:28292836
However, it also comes with some gastrointestinal side effects, including nausea and slowed stomach emptying, which can be linked to acid reflux in some people
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GIP receptor activation may add metabolic effects, though the exact contribution to weight loss can vary by person
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