6 PMC (2022)Reduced-calorie diet with NNMT inhibition establishes a distinct microbiome in DIO mice
Notably, the combination of AOD9604 and HA appeared to offer greater benefits than either agent alone, suggesting a synergistic effect in promoting cartilage protection and repair [1]
Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment
It inhibits the enzyme nicotinamide N-methyltransferase (NNMT)
All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections
Because this product contains benzyl alcohol, it should not be used in newborns or in people who are sensitive to benzyl alcohol