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The realistic answer depends on what "work" means

Eligibility criteria vary, and participation requires informed consent and regular clinical monitoring

Treating a serious condition with supplement can sometimes be hazardous

By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

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A developing area of concern is gut microbial conversion of carnitine into trimethylamine which the liver converts into trimethylamine N oxide or TMAO