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Patients often report their preferences shifting away from beef, pork, dairy, and fried foods towards fruits, leafy greens, and water and plant-forward eating leans into exactly those foods
Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats
Patients must verify the concentration on their medication vial or pen before every injection
These treatment patterns need to change. Meanwhile, more data on tirzepatides impact on a broad five-component cardiovascular end point including all-cause mortality are expected from the placebo-controlled SURMOUNT-MMO outcome trial in 15,000 patients with obesity but no diabetes
That distinction matters, and prescribers should be clear-eyed about it
Starting Dose: Begin at ~100 mcg once daily to assess tolerance
