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The large-scale SELECT trial demonstrated that semaglutide reduced major adverse cardiovascular events by 20% 13
Curr Cardiovasc Risk Rep 19 , 18 (2025)
or a very rapid heartbeat
Clinical trials show that people taking Mounjaro for weight management typically lose between 15-22% of their body weight over 72 weeks, depending on the dose
Liraglutide was approved for weight management in 2014 ( Saxenda ), and semaglutide in a higher dose as Wegovy in 2021
Some people notice changes within 12 weeks (like better sleep or energy), while others may take 48 weeks to see results in areas like fat loss, muscle tone, or skin health
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