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Oxidative stress in chronic kidney diseases is characterized by several distinct pathways: oxidative stress mediated by ROS ( OH), nitrosative stress mediated by RNS (ONOO , NO 2 ), chlorinated stress mediated by chlorinated species (HOCl), and carbonyl stress (Advanced glycation end products, AGEs) (Ling and Kuo 2018)
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They are more commonly associated with iron deficiency anemia but have also been linked to vitamin C deficiency ( Red spots or vertical lines in the nail bed, known as splinter hemorrhage, may also appear during vitamin C deficiency due to weakened blood vessels that rupture easily
Mega dose of vitamin C augments the nephrotoxicity of paracetamol
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