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Anti-Inflammatory and Cytoprotective Reduces systemic inflammation markers
Neuroprotection and Oxidative Stress Pathways DSIP is utilized in research exploring neuroprotection and cellular responses to oxidative stress
In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]
Scientific References Xultophy 100 units/mL + 3.6 mg/mL solution for injection - Summary of Product Characteristics
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