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Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial In TRIUMPH-4, participants with obesity and knee osteoarthritis taking retatrutide 12 mg lost an average of 28.7% of their body weight at 68 weeks Retatrutide reduced WOMAC pain scores by up to an average of 4.5 points (75.8%) and significantly improved measures of physical function, with more than 1 out of 8 retatrutide-treated patients completely free from knee pain at the end of the trial Seven additional Phase 3 trials evaluating the investigational once-weekly treatment in obesity and type 2 diabetes are expected to complete in 2026 1,2 For the co-primary endpoints, retatrutide lowered weight by up to an average of 28.7% (71.2 lbs) and reduced pain by up to an average of 4.5 points (75.8%) using the 3 "People with obesity and knee osteoarthritis often live with pain and restricted mobility, and may eventually require total joint replacement," said TRIUMPH-4 Efficacy Estimand Results In additional secondary endpoints, retatrutide reduced known markers of cardiovascular risk, including non-HDL cholesterol, triglycerides, and high-sensitivity C-reactive protein (hsCRP), and at the highest dose lowered systolic blood pressure by 14.0 mmHg, using the efficacy estimand

Subgroup Analysis Subgroup data provides some perspective on when retatrutide works for whom

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Pucelle The Stunner Eau De Luxe Parfum Body Lotion 67% match with the ingredients and function of Fresh Skinlab Milk White Glutathione Body Lotion Dupe Explained These products are both body lotions that contain niacinamide