Selenoamino acid metabolism and fate of Se-cysteine (mineralization) towards activation of the Se-dependent GSH-Px system
If GI symptoms are severe, the solution is slower dose titration (extending intervals between increases from 4 weeks to 68 weeks), eating smaller meals with lower fat content, and potentially adding ginger or vitamin B6 which have anti-nausea effects through different mechanisms
They are used across a range of laboratory research disciplines due to their potential research applications
Commonly reported adverse effects are generally mild and may include local injection site reactions when administered via parenteral routes
Start with lower doses Jumping straight into high doses overwhelms your system, especially if its your first IV infusion
The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)