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On June 12, 2023, Merck (NYSE: MRK), known as MSD outside of the United States and Canada, announced that new findings for efinopegdutide (MK-6024), an investigational GLP-1/glucagon receptor co-agonist, have been accepted for oral presentation at the European Association for the Study of the Liver (EASL) Annual Congress from June 21-24
In conclusion, combination of metformin and liraglutide has synergistic protective effects on endothelial function
Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 (Arab et al., 2023)
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These may include injection-site redness or minor irritation following subcutaneous administration
