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Phase 3 trials (LIPO-010 and CTR-1011) involving 806 patients demonstrated 19.6% and 11.7% visceral fat reduction respectively
Hormonal shifts regulate adipogenesis and browning of fat
Available evidence indicates that semaglutide reduces all-cause dementia rates when compared with placebo
Peptide Profile Peptide Name: Melanotan II Main Function: Known for stimulating melanogenesis, leading to increased skin pigmentation or tanning
I spoke on the preclinical data of Amylin and its effect on appetite suppression
Effects: * LDL cholesterol * Triglycerides * HDL cholesterol * Stabilizes atherosclerotic plaques * Reduces inflammation in blood vessels Indications * Hypercholesterolemia * Mixed dyslipidemia * Familial hypercholesterolemia * Prevention of: * Myocardial infarction * Stroke * Cardiovascular disease Used in patients with: * Diabetes mellitus * Hypertension * Atherosclerotic cardiovascular disease Dosage Typical adult dose: * 540 mg once daily Common starting doses: * 1020 mg daily * Lower doses in: * Elderly * Renal impairment * Asian patients Maximum: * 40 mg/day Pharmacokinetics * Oral administration * Long half-life (~19 hours) * Mainly hepatic action * Excreted partly unchanged in feces Adverse Effects Common * Headache * Myalgia * Abdominal pain * Nausea * Constipation Serious * Myopathy * Rhabdomyolysis * Hepatotoxicity * New-onset diabetes (rare) Monitoring Before and during therapy: * Lipid profile * Liver function tests * CK level if muscle symptoms occur Contraindications * Active liver disease * Pregnancy * Breastfeeding * Severe hypersensitivity Statins are contraindicated in pregnancy because cholesterol is important for fetal development
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