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doi: 10.1074/jbc.RA119.010130 106 Artavanis-TsakonasSRandMDLakeRJ

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In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients

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