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The MHRA advises appropriate monitoring, especially for patients with a history of diabetic retinopathy, and any concerning symptoms should be reported promptly to a healthcare professional

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Advise reporting persistent abdominal pain (pancreatitis warning)

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One notable distinction: PT-141 does not directly improve penile hemodynamics as potently as a PDE5i, so if a man has severe vascular issues, a PDE5i or injection is needed to get sufficient rigidity