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These mirror the safety profile seen with GLP-1 receptor agonists broadly and are expected given the mechanism of action
GLP-1RA may influence the activity of two opposite subgroup neurons within ARC, which are related to food intake and body weight, containing proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) and neuropeptide Y/agouti related peptide (NPY/AgRP) neurons
Tirzepatide demonstrated an average reduction of ~20% over 72 weeks
Cerebellum 2009
fish and seafood
Biochim Biophys Acta 1830 , 3143-3153(2013)
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