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GRAS status does not equal drug approval, but it does indicate that the regulatory body considered the compound safe for human consumption at the doses tested

Once in the body, B12 works to support the proper functioning of the brain and nervous system, as well as the production of red blood cells and DNA

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The most frequently cited mechanistic findings come from a small group of obese-rodent studies published around the beginning of the 2000s

It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

Well B12 supports methylation