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The trade-off is a higher total cost due to the mandatory membership fee on top of medication

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GLP-1 receptor agonists and the dual agonist tirzepatide modulate appetite, satiety, and gastric emptying, with evidence from STEP (NEJM 2021), SURMOUNT (NEJM 2022), and SURMOUNT-OSA (NEJM 2024)

It does not predict response to a specific medication, but it can provide upstream context for a more informed provider conversation

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Age-related changes in the mitochondria of human mural granulosa cells