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Based on our structural model, we hypothesized that proteolytic cleavage of this loop would lead to increased structural plasticity, particularly for residues 301307, which may, in turn, facilitate its induced-fit binding to HGF

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Long term dosing and discontinuation planning Tirzepatide is designed for long term use, but understanding maintenance strategies and eventual discontinuation planning helps prevent weight regain and metabolic deterioration that commonly follows cessation

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